ncRNA name | LSD1 siRNA |
ncRNA Category | siRNA |
Disease name | diabetic retinopathy (DR) |
Species | Bos taurus |
Tissues/Cell_line | bovine retinal endothelial cells (BRECs) |
Methods | Chromatin immunoprecipitation (CHIP), qPCR, Western blot, Nrf2-DNA binding activity |
Expression pattern | associated |
Functional description | LSD1 siRNA abrogated the glucose-induced decrease in H3K4me1 at Gclc-ARE4 and ameliorated decreases in Nrf2 binding at Gclc-ARE4 and Gclc transcripts. |
PubMed ID | 25016074 |
Year | 2014 |
Title | Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression. |
Drug-related ncRNA | NO |
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